Endothelin-1, aging and hypertension

Role of endothelin-1 in hypertension.

Endothelin-1 (ET-1) was first characterized as a potent vasoconstrictor and is overexpressed in the vasculature in different models of hypertension, such as deoxycorticosterone acetate-salt rats, Dahl salt-sensitive rats, and stroke-prone spontaneously hypertensive rats. Moreover, patients with moderate to severe hypertension present increased vascular levels of prepro-ET-1 mRNA. In addition to...

Role of Endothelin-1 in Clinical Hypertension

Hypertension is the most common risk factor worldwide for cardiovascular morbidity and mortality.1,2 Currently it is estimated that a quarter of the world’s adult population is hypertensive, and this number is projected to increase to 30% by 2025.1 Although, there exist a number of drug therapies for hypertension, blood pressure (BP) control to target is still only achieved in 30% of patients.3...

Endothelin, sex and hypertension.

The ETs (endothelins) comprise a family of three 21-amino-acid peptides (ET-1, ET-2 and ET-3) and 31-amino-acid ETs (ET-1(1-31), ET-2(1-31) and ET-3(1-31)). ET-1 is synthesized from a biologically inactive precursor, big ET-1, by ECEs (ET-converting enzymes). The actions of ET-1 are mediated through activation of the G-protein-coupled ET(A) and ET(B) receptors, which are found in a variety of c...

Correlation of Active Aging and Hypertension Self-Care Behaviors in The Elderly with Hypertension

Introduction: Attention to self-care behaviors is important in the management and control of chronic diseases such as hypertension. The aim of this study was to determine the correlation between active aging and hypertensive self-care behaviors in the elderly with hypertension. Methods: The present study is descriptive-correlation. The statistical population included all the elderly with hyper...

Endothelin, kidney disease, and hypertension.